KK Ladies’s and Youngsters’s Hospital and PacBio Collaborate in Asia’s First Examine of Unexplained Neurodevelopmental Issues

PacBio HiFi sequencing expertise shall be used to research the impression on medical yield of unresolved uncommon ailments in kids

SINGAPORE AND MENLO PARK, Calif., February 16, 2022 (Globe Newswire) — KK Ladies’s and Youngsters’s Hospital (KKH) and PacBio (Nasdaq: PACB), a number one supplier of high-quality, extremely correct sequencing platforms, introduced at the moment Collaboration to leverage PacBio expertise in understanding the genetic causes of neurodevelopmental problems. like an element bBuzz Rsearch Iinnovation for Danalysis of GENETIC DISEASE IN singapore (BRIDGES) program, collaboration will use HiFi lengthy learn sequencing expertise to research the impact on medical yield in unresolved neurodevelopmental dysfunction instances, of which solely 39 % had been resolved utilizing brief learn sequencing strategies .

The collaboration brings collectively two powerhouses of their respective fields. KKH is an instructional medical heart main in Obstetrics, Gynecology, Pediatrics and Neonatology. Its 830 mattress facility is a tertiary referral heart to handle excessive threat situations in ladies and kids. PacBio is a number one supplier of long-read sequencing expertise, and has in depth uncommon disease-focused collaborations with a number of US- and Europe-based organizations.

“Understanding the genetic causes of uncommon, unknown ailments provides affected households some type of closure, together with potential medical choices, and the flexibility to make knowledgeable household planning selections,” mentioned principal investigator of the Singapore Undiagnosed Ailments Program, Dr. Soumya Jamuar, who can also be Senior Advisor, Genetics Service and Head of the SingHealth Duke-NUS Genomic Medication Heart at KKH. “As the primary hospital in Asia to make use of HiFi Lengthy Learn Sequencing expertise, our researchers wish to higher perceive the genetic foundation, or uncommon ailments, within the hope that it’ll ultimately enhance the probabilities of making uncommon illness diagnoses, which permits us to Could assist to supply focused medical administration. Higher well being outcomes for extra households.”

PacBio, together with KKH, may even work to construct a bioinformatics pipeline optimized for HiFi lengthy learn sequencing information evaluation, enabling KKH to determine doubtlessly disease-associated variants, together with structural variants, within the hopes of accelerating diagnostic yield in uncommon illness instances. Allows checking. Suspicious however unknown genetic origin.

Christian Henry, Chief Govt Officer and President of PacBio, mentioned, “By way of this collaboration with main uncommon illness researchers in Singapore, we hope to convey solutions and hope to sufferers and households residing with uncommon, unknown ailments. ” “We’re assured that this system at KKH will function a mannequin for making use of PacBio HiFi sequencing expertise to tough to resolve instances in hospitals in Asia.”

About KK Ladies and Youngsters Hospital

KK Ladies’s and Youngsters’s Hospital (KKH) is Singapore’s largest tertiary referral heart for obstetrics, gynecology, pediatrics and neonatology. Established in 1858, the Institute of Academic Medication specializes within the administration of high-risk situations in ladies and kids. A staff of round 500 consultants take a compassionate, multi-disciplinary and holistic strategy to remedy, and use medical improvements and expertise to offer the perfect medical care.

As an instructional medical centre, KKH is a significant instructing hospital for all three medical colleges in Singapore, the Duke-NUS Medical Faculty, the Yong Lu Lin Faculty of Medication and the Lee Kong Chian Faculty of Medication. The 830-bed hospital additionally runs the biggest specialist coaching program for obstetrics and gynecology and paediatrics within the nation. Each packages are accredited by the Accreditation Council for Graduate Medical Training Worldwide (ACGME-I), and are rated extremely for the top quality of medical instructing and dedication to translational analysis.

PacBio. about
Pacific Biosciences of California, Inc. (NASDAQ: PACB) is empowering life scientists with extremely correct sequencing platforms. The corporate’s modern instruments are based mostly on single molecule, real-time (SMRT®) sequencing expertise, which offers a complete view of the genome, transcriptome and epigenome, enabling entry to the total spectrum of genetic variation in any organism. Cited in hundreds of peer-reviewed publications, PacBio® sequencing methods are in use by scientists world wide to drive discovery in human biomedical analysis, plant and animal science, and microbiology. For extra info please go to www.pacb.com and comply with @PacBio.

PacBio merchandise are offered for analysis use solely. Not in use for diagnostic procedures.

forward-looking statements
This press launch comprises “forward-looking statements” throughout the which means of part 21E of the Securities Trade Act of 1934 and the long run availability, use, accuracy, advantages, high quality or efficiency of using PacBio merchandise or applied sciences, or advantages or anticipated advantages; the suitability or usefulness of such merchandise or applied sciences for specific functions or initiatives in reference to the Bridge Program; Potential enhancement of offering differential identification and solutions for uncommon illness specimens, particularly for the Bridge Program and uncommon illness analysis usually; using PacBio expertise within the improvement of diagnostic or diagnostic assays; and different future occasions. Readers are cautioned to not place undue reliance on these forward-looking statements and any such forward-looking statements are construed solely as a reference to the next warning statements. All forward-looking statements converse solely as of the date of this press launch and are based mostly on present expectations and contain quite a lot of assumptions, dangers and uncertainties that might trigger precise outcomes to vary materially from these of such forward-looking statements. Readers are strongly inspired to learn the total warning statements contained within the Firm’s filings with the Securities and Trade Fee, together with the dangers set out within the Firm’s Varieties 8-Okay, 10-Okay, and 10-Q. The corporate disclaims any obligation to replace or revise any forward-looking statements.

Contact for PacBio
Todd Friedman

kathy lynch

KKH. contact for
Charlotte Samu

Supply hyperlink